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| CAS NO. | 1446502-11-9 |  |
| Product Name | Enasidenib | |
| Synonyms | AG-221 | |
| Formula | C19H17F6N7O | |
| Molecular Weight | 473.14 | |
| Spec / Purity | 98%min | |
| Supply Capacity | ||
| Details | Enasidenib, aslo known as AG-221 and CC-90007, is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2). The mutations of IDH2 present in certain cancer cells result in a new ability of the enzyme to catalyze the NAPH-dependent reduction of α-ketoglutarate to R(-)-2-hydroxyglutarate (2HG). The production of 2HG is believed to contribute to the formation and progression of cancer . The inhibition of mutant IDH2 and its neoactivity is therefore a potential therapeutic treatment for cancer. | |
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