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| CAS NO. | 552292-08-7 |  |
| 英文品名 | Rolapitant | |
| 中文品名 | 罗拉吡坦 | |
| 分子式 | C25H26F6N2O2 | |
| 分子量 | 500.48 | |
| 规格/纯度 | 98%min | |
| 供应能力 | ||
| 别名 | sch619734 | |
| 详细说明 | Rolapitant, also known as SCH-619734, is a selective, bioavailable, CNS penetrant neurokinin NK1 receptor antagonist that shows behavioral effects in animals models of emesis. In vitro studies indicate that rolapitant has a high affinity for the human NK1 receptor of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of >1000-fold. Rolapitant is a functionally competitive antagonist, as measured by calcium efflux, with a calculated Kb of 0.17 nM. | |
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